
I've played this card in a couple of decks now, and while it's solid just as a recurring skill boost, it feels like the real powerhouse use is in Short Supply/Scavenging or Short Supply/Yorick decks.
Those decks often have a weird dip in power in the mid-late game, because with a little draw acceleration, you end up reshuffling your deck. This puts your weaknesses back into your card pool and cripples your recurrence. With Persistence however, you can consistently stop yourself from decking out, which lets you sit at your most powerful board state indefinitely.