Unless I'm missing something, even George would prefer Nothing Left to Lose most of the time.

This requires waiting to accumulate supplies (starts with 2, but the other can give up to 5). That's not great if you need the money now.

Nothing Left to Lose also gives card draw, which George usually can take advantage of.

This costs one resource, for a card that you use when you're short on resources.

Nothing Left to Lose has a ? symbol in case you don't need it when you get it. (Marginal benefit, but it's there).

Pro: this can be re-used, when you re-shuffle your deck, I guess.

1 less xp here, even though survivors usually have extra xp laying around.

I today received the below ruling through the official rules question forum, which gives this weakness rather more teeth than I and others originally anticipated:

"If Gloria looks at multiple copies of Prophecy of the End with her ability, each “Forced” ability on the treacheries resolves, and each are placed facedown beneath Gloria."

Since, unlike Hawk-Eye Folding Camera, the reaction ability has no limit, we have yet another card that enables Luke Robinson to break the game. Move clues to your Dream-Gate, drop them (e.g., Bizarre Diagnosis, Captivating Discovery, Analysis, Quick Study, Forewarned, Dr. William T. Maleson), or just use Luke's own ability or Pocket Telescope to snatch them out of the bunker and power up your Enchanted Bow* for sniping enemies off your team's back.

*Hand slots are no issue due to, e.g., Astral Mirror, Arcane Enlightenment, The Raven Quill.

At this point, I all but wonder why they did not just allow the charges to be spent for Relic assets to power up the Gate Box as well...

something to keep an eye on for investigators that have one stat that is quite high and one that is quite low (eg Gloria Goldberg with 5 and 1 )

it converts a success on a treachery you're able to handle into free relief from a treachery card you couldn't

note that currently every investigator who could run Dreams of the Clay minus Lucius Galloway can already run Ward of Protection, and in my opinion the 1 horror and 1 resource is worth the Spell trait, saved xp, and reduced variance.

Patrice Hathaway might prefer Dreams due to not being able to hold on to her Wards, but it still relies on her (or an investigator at her location) drawing a passable treachery test on the same round as drawing Dreams

Archibald seems very powerful when comboed with Library Pass (5) to turn all of your secret using tomes into resource events. Library Pass (5) encourages you to "read" your books as fast as possible and get rid of them so you don't have to pay any of the late fees, but lots of Tomes either exhaust, like Scroll of Secrets or Old Book of Lore or have too many secrets to use in just one turn like Scroll of Prophecies and Grim Memoir. With Archibald, you'll never waste any secrets so long as you have pricy insight events to bankroll. This combo is available to any Scholar investigators, and one half of it is even a permanent card. But of course, Seeker Agatha has access to every insight event in the game and an extra action to play them through her ability.